Invention Patent
AT202927T
未知
- Patent Title:
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Application No.: AT94301026Application Date: 1994-02-11
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Publication No.: AT202927TPublication Date: 2001-07-15
- Inventor: HERBIG SCOTT M , SMITH KELLY L
- Applicant: PFIZER
- Assignee: PFIZER
- Current Assignee: PFIZER
- Priority: US2322793 1993-02-25
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/22 ; A61K9/28 ; A61K9/48 ; A61K9/50 ; A61K9/52 ; A61K45/00 ; A61K47/32 ; A61K47/38 ; A61P43/00
Abstract:
An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.]
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