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    2.
    发明专利
    未知

    公开(公告)号：PT612520E

    公开(公告)日：2001-12-28

    申请号：PT94301026

    申请日：1994-02-11

    Applicant: PFIZER

    Inventor： HERBIG SCOTT M ,  SMITH KELLY L

    IPC: A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K45/00 ,  A61K47/32 ,  A61K47/38 ,  A61P43/00

    Abstract: An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.]

    5.
    发明专利
    未知

    公开(公告)号：FI940866A0

    公开(公告)日：1994-02-24

    申请号：FI940866

    申请日：1994-02-24

    Applicant: PFIZER

    Inventor： HERBIG SCOTT M ,  SMITH KELLY L

    IPC: A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K45/00 ,  A61K47/32 ,  A61K47/38 ,  A61P43/00 ,  A61K

    Abstract: An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.]

    8.
    发明专利
    未知

    公开(公告)号：DE69427664D1

    公开(公告)日：2001-08-16

    申请号：DE69427664

    申请日：1994-02-11

    Applicant: PFIZER

    Inventor： HERBIG SCOTT M ,  SMITH KELLY L

    IPC: A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K45/00 ,  A61K47/32 ,  A61K47/38 ,  A61P43/00

    Abstract: An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.]

    9.
    发明专利
    未知

    公开(公告)号：AT202927T

    公开(公告)日：2001-07-15

    申请号：AT94301026

    申请日：1994-02-11

    Applicant: PFIZER

    Inventor： HERBIG SCOTT M ,  SMITH KELLY L

    IPC: A61K9/00 ,  A61K9/22 ,  A61K9/28 ,  A61K9/48 ,  A61K9/50 ,  A61K9/52 ,  A61K45/00 ,  A61K47/32 ,  A61K47/38 ,  A61P43/00

    Abstract: An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.]

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