The invention discloses an interference measurement method and system and related equipment. The method includes the steps that demodulation interference measurement resources (DM-IMR) are configured for a target data channel of a terminal by a network side, and the positions of the DM-IMR in a frequency domain are determined according to a physical resource block (PRB) bearing the target data channel; the configuration information of the DM-IMR is indicated to the terminal by the network side so that the transmission interference in the target data channel can be measured by the terminal conveniently. Due to the scheme, the transmission interference in the target data channel can be measured more accurately, the demodulation/decoding performance of the target data channel on a receiving side can be improved easily, and the receiving performance of the target data channel can be improved.