Disclosed are an interference measurement method and system, and related equipment. The method includes: a network side configures Interference Measurement Resources for Demodulation (DM-IMRs) for a target data channel of a terminal, positions of the DM-IMRs on a frequency domain being determined according to a Physical Resource Block (PRB) which bears the target data channel; and the network side indicates configuration information of the DM-IMRs to the terminal to enable the terminal to perform transmission interference measurement on the target data channel. By the solutions of the present disclosure, accuracy in transmission interference measurement of the target data channel may be improved, so that improvement in demodulation/decoding performance of the target data channel at a receiving side is facilitated, and receiving performance of the target data channel may further be improved.