The invention discloses an interface protection device. The interface protection device is arranged in a first device and comprises a detection unit and a connection unit, wherein the connection unit is connected with an exposed contact of the first device, an internal circuit of the first device and the detection unit, the detection unit is used for sending a connection signal to the connection unit when an external wire gets close to or is connected with the exposed contact and is not used for sending the connection signal to the connection unit when the external wire deviates from or is disconnected with the exposed contact, the external wire is a data line or a charging line of the first device, and the connection unit is used for making the exposed contact and the internal circuit connected when the connection signal sent by the detection unit is received and making the exposed contact and the internal circuit disconnected when the connection signal sent by the detection unit is not received. The invention also discloses an interface protection method.