The invention provides a topological interference alignment method of an MIMO interference broadcast channel for solving the technical problem that the topological interference alignment of generalized MIMO cannot be realized in the prior art. The method comprises the following steps: setting the system; constructing a partial connection model of MIMO IBC, and then converting the same into the partial connection model of MIMO IC through virtual base station expansion; solving a precoding matrix and a decoding matrix of an MIMO IC system satisfying a topological interference condition; designing an MIMO IBC precoding matrix and a decoding matrix, and eliminating inter-cell interference through proper signal processing technology; and designing a precoding matrix of a base station to eliminate intra-cell interference. By adoption of the topological interference alignment method provided by the invention, the topological interference alignment of generalized MIMO IBC can be realized, and a lower limit of a degree of freedom that can be reached by the MIMO IBC system with given topological information can be analyzed.