The tire fault portion prediction system of this disclosure comprises: a tire running parameter measurement unit, a state characteristic value measurement unit, a degree of fatigue characteristic value calculation unit, and a tire fault portion prediction unit for predicting fault portions of a tire based on a degree of fatigue characteristic value of at least one of the tire constituent members and the tire running parameter. The tire fault portion prediction method of this disclosure comprises: measuring a tire running parameter, measuring state characteristic values, calculating degree of fatigue characteristic values, and predicting fault portions of a tire based on a degree of fatigue characteristic value of at least one of the tire constituent members and the tire running parameter.