The invention discloses a fault prediction method and fault prediction platform of a vehicle-mounted equipment system. The method comprises steps of establishing a simulation environment, acquiring historical information, acquiring state information, and predicting a fault trend. The platform is composed of a system setting module, an information communication module, a state monitoring module and a simulation testing module. Therefore, a problem that vehicle reliability can not be guaranteed because of many vehicle types, large vehicle number, or a few of maintenance staff members in the prior art is solved. Different applications can be unified to one platform to carry out fault-prediction-based simulation testing and verification, so that a defect that an independent development simulation platform needs to be established for each application is overcome. Therefore, the development costs are saved; the development cycle is shortened; and the development efficiency is improved.