The present invention relates to a driving method of a display panel and a display device. The method comprises a step of dividing a pixel into a plurality of pixel groups, a step of sequentially displaying each picture by using multiple frames of images, and dividing the multiple frames of images into a first frame unit and a second frame unit with an equal frame number, a step of obtaining a first voltage signal and a second voltage signal of each pixel group in each frame of image, a step of adjusting the first voltage signal and the second voltage signal such that average signals of all first voltage signals of the frames of images are the same, average signals of all second voltage signals of the frames of images are the same, average signals of first voltage signals of different pixel groups at the multiple frames of images are the same, and average signals of second voltage signals of different pixel groups at the multiple frames of images are the same. According to the above driving method, the display quality of the display panel is improved.