The present invention relates to a driving method of a display panel and a display device of. The method includes the following steps that: pixels are divided into a plurality of pixel groups, whereineach pixel group includes a first pixel unit and a second pixel unit which are adjacent to each other; each picture is displayed with a plurality of frames of images which are displayed sequentially;the first voltage signal and second voltage signal of each pixel group in each frame of image are acquired; and the first voltage signals and the second voltage signals are adjusted, so that the average signals of all the first voltage signals of the images are identical, the average signals of all the second voltage signals of the images are identical, the average signals of the first voltage signals of the different pixel groups in the images are identical, and the average signals of the second voltage signals of the different pixel groups in the images are identical. With the above drivingmethod adopted, the problem of brightness flicker in picture display can be solved.