A method for driving a display panel and a display device, the driving method comprising: dividing a pixel into a plurality of pixel groups, each pixel group comprising an adjacent first pixel unit and second pixel unit (S100); displaying each picture in sequence by using a plurality of images (S200); acquiring a first voltage signal and a second voltage signal of each pixel group in each image (S300); adjusting the first and second voltage signals such that the average signal of all of the first voltage signals of each image is the same, and the average signal of all of the second voltage signals of each image is the same, the average signal of first voltage signals of different pixel groups in the plurality of images being the same, and the average signal of second voltage signals of different pixel groups in the plurality of images being the same (S400).