The invention discloses manufacturing information physical system architecture based on cloud-client. The manufacturing information physical system architecture based on the cloud-client comprises a terminal part and an on-cloud part; the terminal part comprises an equipment layer and a control layer; the on-cloud part comprises a data layer and a decision support layer; the equipment layer comprises manufacturing equipment and a wireless sensor network thereon; the control layer comprises a controller of the manufacturing equipment, an industrial computer and a mobile terminal; the data layercomprises data storage service and clustering analysis, prediction modelling, and equipment state monitoring; the decision support layer comprises integrated optimization service and self-adaptive optimization service. Based on the cloud-client, the collection and analysis of the equipment data, the integrated optimization on four aspects of the processing parameter, the processing path, the processing technique and scheduling are realized by adopting the equipment-data-decision support-control four-layer architecture, a self-adaptive optimization scheme in response to various dynamic eventsin the manufacturing procedure is provided, and the automatic optimal configuration of the production way is realized.