The invention provides a mobile phone charging cable with automatic power-off function, which is characterized in that the USB charging cable comprises a USB charging cable, one end of which is arranged as an input terminal DC1, and the other end of which is arranged as an output terminal DC2, and is connected between the input terminal DC1 and the output terminal DC2 through an anti-overcharge circuit. As that circuit of the traditional USB char cable is improved, the battery in the mobile phone is not overcharge after being charged, the battery in the mobile phone is protect from being charged, the service life of the lithium battery in the mobile phone is prolonged, and the power consumption is saved. At the same time to prevent the mobile phone battery overcharge heat generation, to ensure the safety of life and property.