The invention belongs to the manufacturing process, and particularly relates to an vacuum chamber support welding block assembly manufacturing process. The vacuum chamber support welding block assembly manufacturing process comprises the following steps that S1, the machining process of the welding end groove of a supporting block is simulated through a three-dimensional technology, a processing step and a scheme are formulated, and a three-dimensional curve groove is machined; S2, an assembly welding mold is manufactured, and the mold shape is matched with the shape of the part to be welded;S3, mechanical processing steps are carried out. The vacuum chamber support welding block assembly manufacturing process has the remarkable effects that the support block and the middle plane window are controlled to be welded, and the problem that the outer welding meat is not symmetric along the blunt edge is solved; the controllability of the welding deformation is guaranteed; the stability andthe processing precision of the machining process are ensured; and the probability that the product will go wrong due to incorrect processing procedures is greatly reduced.