The invention relates to the technical field of capsule production. A capsule shell-medicine separation mechanism comprises a frame, a support ring, a shell-medicine separation screen, and a verticalrotating shaft rotationally connected to the frame; a capsule queuing positioning column is arranged on the vertical rotating shaft, and is provided with multiple capsule storage through holes distributed in the peripheral direction of the capsule queuing positioning column and axially extending to queue capsules vertically; multiple annular cutter feeding grooves peripherally extending and distributed in the axial direction of the capsule queuing positioning column are arranged on the peripheral surface of the capsule queuing positioning column; the support ring and the frame are connected together, and sleeve the vertical rotating shaft to stop at the lower ends of the capsule storage through holes aligned to the support ring; the support ring is provided with a capsule unloading gap; and the frame is provided with multiple blades correspondingly inserted in the cutter feeding grooves one to one for cutting off capsules in the capsule storage through holes. The capsule shell-medicineseparation mechanism solves the problem of power waste in medicine-shell separation through manual shearing and screening of the capsules.