The invention relates to a wireless multi-hop network coding aware route based on improved coding conditions and gain guarantee, which comprises the following steps of: (1) reducing data transmissiontimes and improving throughput and transmission efficiency of a wireless multi-hop network by using inter-flow network coding; (2) calculating the network coding opportunities of nodes by utilizing improved network coding conditions, discovering network coding opportunities of most two data streams , so as to avoide the problem that a destination node cannot decode, improve the accuracy of network coding discovery and reduce the expenditure of network coding discovery is reduced; and (3) calculating the actual network coding gain by using a coding gain guarantee mechanism to ensure that the network coding can improve the routing performance. According to the invention, an improved network coding condition and a gain guarantee mechanism are applied to network coding perception routing, theexpenditure of network coding opportunity discovery is reduced, the accuracy of the network coding opportunity is improved, the network coding opportunity is ensured to play a positive gain effect onrouting transmission, the routing transmission efficiency is improved, and the network throughput is improved.