Invention Grant
- Patent Title: Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
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Application No.: US15104807Application Date: 2014-12-17
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Publication No.: US10039809B2Publication Date: 2018-08-07
- Inventor: Weijun Shen , Pengyu Yang , Huafei Zou , Peter G. Schultz
- Applicant: THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH , THE SCRIPPS RESEARCH INSTITUTE
- Applicant Address: US CA La Jolla US CA La Jolla
- Assignee: THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH,THE SCRIPPS RESEARCH INSTITUTE
- Current Assignee: THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH,THE SCRIPPS RESEARCH INSTITUTE
- Current Assignee Address: US CA La Jolla US CA La Jolla
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2014/070977 WO 20141217
- International Announcement: WO2015/095406 WO 20150625
- Main IPC: A61K31/23
- IPC: A61K31/23 ; A61K31/20 ; A61K47/48 ; A61K47/30 ; A61K38/22 ; A61K9/00 ; A61K38/26 ; A61K45/06 ; A61K47/60 ; A61K47/54 ; A61K9/70
Abstract:
Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
Public/Granted literature
- US10010589B2 Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof Public/Granted day:2018-07-03
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