公开(公告)号：US20250166731A1

公开(公告)日：2025-05-22

申请号：US18833305

申请日：2023-01-27

Applicant: The Scripps Research Institute

Inventor： Ali Torkamani ,  Raquel Dias

IPC: G16B30/10 ,  G06N3/0455 ,  G06N3/048 ,  G06N3/0495 ,  G06N3/084 ,  G06N3/088 ,  G06N3/0985 ,  G16B20/20 ,  G16B20/40

Abstract: The invention relates to the use of artificial neural networks, such as autoencoders, in population genomics and individual genome processing to fill-in missing data from genomic assays with significant sparsity, such as low-pass whole genome sequencing or array-based genotyping. An autoencoder-based neural network approach for the simultaneous execution of genetic imputation as well as feature extraction and dimensionality reduction for downstream tasks is provided.

公开(公告)号：US12281142B2

公开(公告)日：2025-04-22

申请号：US17335244

申请日：2021-06-01

Applicant: International AIDS Vaccine Initiative, Inc. ,  The Scripps Research Institute

Inventor： Jon M. Steichen ,  William R. Schief

IPC: C07K14/16 ,  A61K9/51 ,  A61K38/00 ,  A61K39/21 ,  C07K16/10 ,  C12N7/00

Abstract: The present disclosure relates to recombinant HIV Env polypeptides and their use in the treatment and prevention of HIV/AIDS.

公开(公告)号：US12269869B2

公开(公告)日：2025-04-08

申请号：US17461365

申请日：2021-08-30

Applicant: The Scripps Research Institute

Inventor： Travis S. Young ,  Leonard Presta ,  David Rodgers ,  Eric Hampton ,  Timothy Wright ,  Peter G. Schultz ,  Eduardo Laborda ,  Elvira Khialeeva ,  Sophie Viaud

IPC: C07K16/18 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  A61K39/00

Abstract: The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

公开(公告)号：US20250059238A1

公开(公告)日：2025-02-20

申请号：US17299062

申请日：2019-12-03

Applicant: Dennis R. BURTON ,  Raiees ANDRABI ,  International AIDS Vaccine Initiative ,  The Scripps Research Institute

Inventor： Dennis R. BURTON ,  Raiees ANDRABI

IPC: C07K14/005 ,  A61K39/21

Abstract: The present disclosure relates to recombinant HIV Env polypeptides and their use in the treatment and prevention of HIV/AIDS.

公开(公告)号：US20250051846A1

公开(公告)日：2025-02-13

申请号：US18807117

申请日：2024-08-16

Applicant: The Scripps Research Institute ,  Northwestern University

Inventor： Sunil M. Kurian ,  Michael M. Abecassis ,  John J. Friedewald

IPC: C12Q1/6883 ,  C12Q1/6881 ,  G16B25/10 ,  G16B50/20

Abstract: This disclosure provides methods of detecting sub-acute rejection and other categories of rejection in kidney transplant recipients using unique sets of gene expression markers.

公开(公告)号：US20250002844A1

公开(公告)日：2025-01-02

申请号：US18747243

申请日：2024-06-18

Applicant: The Scripps Research Institute

Inventor： Wenlin Li ,  Sheng Ding

IPC: C12N5/0735 ,  C12N5/074

Abstract: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.

公开(公告)号：US20240343782A1

公开(公告)日：2024-10-17

申请号：US18734520

申请日：2024-06-05

Applicant: Theraclone Sciences, Inc. ,  International AIDS Vaccine Initiative, Inc. ,  The Scripps Research Institute

Inventor： Po-Ying Chan-Hui ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Marjorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos ,  Stephen Kaminsky

IPC: C07K16/10 ,  A61K39/00 ,  A61K39/21 ,  A61P31/14

CPC classification number: C07K16/1045 ,  A61K39/21 ,  A61P31/14 ,  C07K16/1063 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

公开(公告)号：US20240238426A1

公开(公告)日：2024-07-18

申请号：US18548630

申请日：2022-03-04

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Christopher Parker ,  Wei Wang ,  Li Yun Chen

IPC: A61K47/55 ,  A61K47/54

CPC classification number: A61K47/55 ,  A61K47/542 ,  A61K47/545

Abstract: Compositions and methods for control and/or modification of endogenous protein acetylation are described. The compositions are directed to heterobifunctional molecules having protein and enzyme binding moieties linked together by an organic linker group. The compositions are selective for binding to certain endogenous proteins and function to recruit acety lation enzymes to acetylate or deacety late the proteins.

公开(公告)号：US20240233873A9

公开(公告)日：2024-07-11

申请号：US18547705

申请日：2022-02-24

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Andrew B. Ward ,  Aleksandar Antanasijevic ,  Charles Bowman ,  Christopher Cottrell ,  Gabriel Ozorowski ,  Robert Kirchdoerfer

IPC: G16B30/10 ,  G01N33/577

CPC classification number: G16B30/10 ,  G01N33/577

Abstract: Provided herein are methods for discovery of epitope specific monoclonal antibodies to pathogens directly from immune sera for immunotherapeutic use. Further provided herein are methods to determine molecular structure of antibodies targeting an antigen from convalescent or vaccinated individuals for the purpose of rational vaccine design.

公开(公告)号：US20240226272A9

公开(公告)日：2024-07-11

申请号：US18257808

申请日：2021-12-17

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： William R. SCHIEF ,  Torben SCHIFFNER ,  Jon M. STEICHEN ,  Xiaozhen HU

IPC: A61K39/215 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88

CPC classification number: A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88 ,  A61K2039/53 ,  C12N2740/16034 ,  C12N2760/20034 ,  C12N2770/20034 ,  C12Y402/0101

Abstract: Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.