Invention Grant
- Patent Title: Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
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Application No.: US15529615Application Date: 2015-12-01
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Publication No.: US10077242B2Publication Date: 2018-09-18
- Inventor: Frank Gupton , Alex Martin , Ali Siamaki , Katherine Belecki
- Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
- Applicant Address: US VA Richmond
- Assignee: Virginia Commonwealth University
- Current Assignee: Virginia Commonwealth University
- Current Assignee Address: US VA Richmond
- Agency: W&C IP
- International Application: PCT/US2015/063152 WO 20151201
- International Announcement: WO2016/089845 WO 20160609
- Main IPC: C07D235/20
- IPC: C07D235/20 ; C07D403/04 ; B01J23/44 ; B01J21/18 ; B01J31/22 ; B01J31/24 ; B01J35/00
Abstract:
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.
Public/Granted literature
- US20170260146A1 A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION Public/Granted day:2017-09-14
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