A mechanism is described for facilitating callback interrupt handling for multi-threaded applications in computing environments. A method of embodiments, as described herein, includes detecting a task issued by a thread associated with an application processor, where the task is to be processed by a graphics processor at the apparatus. The method may further include scheduling the task at the graphics processor, and emulating an interrupt to the application processor, where the emulated interrupt disables one or more graphics interrupts while the task is being processed by the graphics processor. The method may further include facilitating an interrupt handler to communicate a signal to the application processor to wake up the thread, where the thread is facilitated to perform one or more tasks independent of the task being processed by the graphics processor.