Invention Grant
- Patent Title: Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
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Application No.: US14916338Application Date: 2014-09-04
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Publication No.: US10167466B2Publication Date: 2019-01-01
- Inventor: Stephanie Fanucchi , Youtaro Shibayama , Shaun Burd , Musa M. Mhlanga
- Applicant: CSIR
- Applicant Address: ZA Pretoria
- Assignee: CSIR
- Current Assignee: CSIR
- Current Assignee Address: ZA Pretoria
- Agency: McBee Moore Woodward & Vanik IP, LLC
- Agent Susan McBee
- Priority: ZA2013/06649 20130904
- International Application: PCT/IB2014/064259 WO 20140904
- International Announcement: WO2015/033293 WO 20150312
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N15/01 ; C12N9/22 ; C12N15/63 ; C12Q1/6841 ; C12Q1/6876
Abstract:
This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell and to methods of silencing gene expression in a cell by way of perturbing gene regulatory elements which are engaged in chromosomal contact.
Public/Granted literature
- US20160215280A1 Site-Specific Nuclease Single-Cell Assay Targeting Gene Regulatory Elements to Silence Gene Expression Public/Granted day:2016-07-28
Information query
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