Invention Grant
- Patent Title: Real-time imaging sensor for measuring cellular thiol level
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Application No.: US15527816Application Date: 2015-11-18
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Publication No.: US10215757B2Publication Date: 2019-02-26
- Inventor: In-Gyu Kim , Ki Hang Choi , Eui Man Jeong , Heun Soo Kang
- Applicant: CELL2IN, INC. , SNU R&DB FOUNDATION , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- Applicant Address: KR KR KR
- Assignee: CELL2IN, INC.,SNU R&DB FOUNDATION,KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- Current Assignee: CELL2IN, INC.,SNU R&DB FOUNDATION,KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- Current Assignee Address: KR KR KR
- Agency: Sheridan Ross P.C.
- Priority: KR10-2014-0161860 20141119
- International Application: PCT/KR2015/012415 WO 20151118
- International Announcement: WO2016/080759 WO 20160526
- Main IPC: G01N33/58
- IPC: G01N33/58 ; G01N33/50 ; C07D491/16
Abstract:
The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
Public/Granted literature
- US20170307624A1 REAL-TIME IMAGING SENSOR FOR MEASURING CELLULAR THIOL LEVEL Public/Granted day:2017-10-26
Information query
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