A device 1 for generating a controlled ionic flow I is described. The device 1 is portable and comprises an ionization chamber 6, at least one inlet member 2 and at least one ion outlet member 3. The ionization chamber 6 is suitable to be kept at a vacuum pressure, and configured to ionize gaseous particles contained therein. The at least one inlet member 2 is configured to inhibit or allow and/or adjust an inlet in the ionization chamber of a gaseous flow Fi of said gaseous particles. In addition, the at least one inlet member 2 comprises a gaseous flow adjusting interface 22, having a plurality of nano-holes 20, of sub-micrometric dimensions, suitable to be opened or closed, in a controlled manner, to inhibit or allow a respective plurality of gas micro-flows through the at least one inlet member 2.