Methods and systems for managing pricing guarantees for prescription drugs are described. In one embodiment, a designation of a pharmacy within a pharmacy network may be received as a preferred pharmacy designation. The preferred pharmacy designation may be associated with a member. A set of preferred pharmacy benefits may be associated with the member and the preferred pharmacy designation. A pharmacy claim associated with the preferred pharmacy designation for a prescription for the member may be adjudicated based on the set of preferred pharmacy benefits. Other methods and systems are described.