Systems and methods are provided for digital-to-analog conversions with adaptive digital offsets. A digital offset may be determined and applied to a digital input to a digital-to-analog converter (DAC), and digital-to-analog conversions are then applied via the DAC to the digital input with the digital offset. The digital offset may be set to account for one or more conditions relating to inputs to the DAC, with the one or more conditions affecting switching characteristics of one or more of a plurality of conversion elements in the DAC. The digital offset may be determined dynamically and adaptively, such as based on the input and/or conditions relating to the input. The adjustments may be selectively applied to the digital offset for particular input conditions.