The present invention provides a mouse with a soundless scroll wheel module, including a mouse body and a soundless scroll wheel module. The soundless scroll wheel module includes a supporting frame, a scroll wheel body, a mute inner ratchet wheel, a strut, an elastic component, and an encoding component. The mute inner ratchet wheel is installed in the scroll wheel body. The strut includes an engagement segment and the engagement segment is engaged with the mute inner ratchet wheel. The mute inner ratchet wheel comprises a flexible annular body and multiple flexible ratchets for reducing rolling noise.