- Patent Title: Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing same as active ingredient
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Application No.: US15567692Application Date: 2016-06-01
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Publication No.: US10526337B2Publication Date: 2020-01-07
- Inventor: Ge Hyeong Lee , Hee-Jong Lim , Heeyeong Cho , Woo Kyu Park , Seong Hwan Kim , Jung Hwan Choi
- Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Chemical Technology
- Current Assignee: Korea Research Institute of Chemical Technology
- Current Assignee Address: KR Daejeon
- Agency: Greenberg Traurig, LLP
- Priority: KR10-2015-0086372 20150618; KR10-2016-0067210 20160531
- International Application: PCT/KR2016/005798 WO 20160601
- International Announcement: WO2016/204429 WO 20161222
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/506 ; C07D471/04
Abstract:
The present invention relates to a heteroaryl derivative represented by Formula 1 wherein , A, R1, R2, R3, R4, and R5 are as defined herein, or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as cancers, autoimmune diseases, and respiratory diseases.
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