A heat dissipation system with air sensation function includes a chassis, multiple fans, multiple air sensation units and an external control device connected to the fans. The chassis has an installation face for installing the fans thereon. The air sensation units are respectively disposed on the fans for detecting the air state of the corresponding fans to generate an air sensation signal. The external control device serves to receive the air sensation signal transmitted from the air sensation units and compare the data contained in the air sensation signal with preset data so as to control/adjust the rotational speed of the corresponding fans. Accordingly, a uniform airflow flows out of the fans to effectively lower the noise.