Invention Grant
- Patent Title: Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
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Application No.: US15644876Application Date: 2017-07-10
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Publication No.: US10550420B2Publication Date: 2020-02-04
- Inventor: Lance P. Encell , Mary P. Hall , Keith V. Wood , Monika G. Wood
- Applicant: PROMEGA CORPORATION
- Applicant Address: US WI Madison
- Assignee: Promega Corporation
- Current Assignee: Promega Corporation
- Current Assignee Address: US WI Madison
- Agency: Casimir Jones, S.C.
- Agent Peter J. Schlueter
- Main IPC: C12Q1/66
- IPC: C12Q1/66 ; G01N33/542 ; C12N9/02 ; G01N21/64 ; G01N33/68
Abstract:
Provided herein are isolated polynucleotide encoding modified click beetle luciferase polypeptides that have enhanced luminescence and longer wavelength near-infrared signals. The disclosure also relates to near-infrared bioluminescence systems that include said modified click beetle luciferase polypeptides and novel luciferin derivatives, as well as methods of using said modified click beetle luciferase polypeptides and bioluminescence systems.
Public/Granted literature
- US20170314061A1 NOVEL LUCIFERASE SEQUENCES UTILIZING INFRARED-EMITTING SUBSTRATES TO PRODUCE ENHANCED LUMINESCENCE Public/Granted day:2017-11-02
Information query
