Invention Grant
- Patent Title: Chemical modulators of immune checkpoints and therapeutic use
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Application No.: US16191243Application Date: 2018-11-14
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Publication No.: US10562864B2Publication Date: 2020-02-18
- Inventor: Wei Chen , Herbert Kim Lyerly , Xiu-rong Ren , Jiangbo Wang , Hongtao Guo , Amy Hobeika , Robert A. Mook, Jr.
- Applicant: Duke University
- Applicant Address: US NC Durham
- Assignee: Duke University
- Current Assignee: Duke University
- Current Assignee Address: US NC Durham
- Agency: Michael Best & Friedrich LLP
- Main IPC: C07D249/08
- IPC: C07D249/08 ; C07D235/18 ; A61K31/4196 ; A61K31/4184 ; A61K45/06
Abstract:
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.
Public/Granted literature
- US20190077772A1 CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE Public/Granted day:2019-03-14
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