A multi-port hybrid-based cancellation network may include a first and second hybrid coupler, and a first and second two-port network. The second hybrid coupler may be distinct from the first hybrid coupler. The first two-port network may include a first filter connected between the first and the second hybrid couplers. The second two-port network may include a second filter that is distinct from but essentially the same as the first filter connected between the first and the second hybrid couplers. Other circuitry components may be connected to one of the ports of multi-port hybrid-based cancellation network. These other circuitry components may have a configuration that increases or maximizes signal isolation between at least two of the ports of the multi-port hybrid-based cancellation network.