The invention provides co-registration systems and methods for detecting endoleaks associated with aneurysm repair. The system includes an imaging device having expanded imaging capabilities and configured to capture and provide image data and flow visualization of a vessel based on the image data. The system further includes one or more sensors for capturing functional parameters of the vessel, such as flow or pressure. The system further includes an external imaging modality for capturing external image data of the vessel, such as, for example, a radiological image. The co-registration system is configured to co-register sets of data captured by a plurality of intra- and extraluminal modalities and provide a composite map (3- or multi-dimensional) of the vessel including automatically detected areas of interest, particularly during an EVAR or TEVAR procedure.