Invention Grant
- Patent Title: Method for preparation of reducible degradable hyperbranched polymeric micelles
-
Application No.: US15780320Application Date: 2016-07-29
-
Publication No.: US10576038B2Publication Date: 2020-03-03
- Inventor: Caihua Ni , Yamin Zhou , Liping Zhang , Gang Shi
- Applicant: JIANGNAN UNIVERSITY
- Applicant Address: CN Wuxi, Jiangsu
- Assignee: JIANGNAN UNIVERSITY
- Current Assignee: JIANGNAN UNIVERSITY
- Current Assignee Address: CN Wuxi, Jiangsu
- Agency: VLP Law Group LLP
- Agent Enshan Hong
- Priority: CN201510971607 20151221
- International Application: PCT/CN2016/092187 WO 20160729
- International Announcement: WO2017/107486 WO 20170629
- Main IPC: A61K9/107
- IPC: A61K9/107 ; C08G83/00 ; A61K47/34 ; B01J13/04 ; B01J13/16

Abstract:
Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.
Public/Granted literature
- US20180360753A1 A METHOD FOR PREPARATION OF REDUCIBLE DEGRADABLE HYPERBRANCHED POLYMERIC MICELLES Public/Granted day:2018-12-20
Information query