公开(公告)号：US11191728B2

公开(公告)日：2021-12-07

申请号：US16928186

申请日：2020-07-14

Applicant: JIANGNAN UNIVERSITY

Inventor： Caihua Ni ,  Zhenle Tian ,  Gang Wang ,  Liping Zhang ,  Ren Liu

IPC: A61K31/704 ,  A61K9/19 ,  C08G63/06 ,  C08J3/14 ,  C08J3/075

Abstract: A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

公开(公告)号：US10576038B2

公开(公告)日：2020-03-03

申请号：US15780320

申请日：2016-07-29

Applicant: JIANGNAN UNIVERSITY

Inventor： Caihua Ni ,  Yamin Zhou ,  Liping Zhang ,  Gang Shi

IPC: A61K9/107 ,  C08G83/00 ,  A61K47/34 ,  B01J13/04 ,  B01J13/16

Abstract: Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.

公开(公告)号：US11510874B2

公开(公告)日：2022-11-29

申请号：US17139566

申请日：2020-12-31

Applicant: JIANGNAN UNIVERSITY

Inventor： Liping Zhang ,  Caihua Ni ,  Xinxin Sang ,  Gang Shi

IPC: A61K9/107 ,  C08F220/38 ,  C08F220/58 ,  A61K9/19 ,  A61K31/704 ,  A61K47/32

Abstract: A method for making reduction sensitive nano micelles comprising: 1) dissolving taurine in distilled water, and adding sodium hydroxide solution; 2) dissolving acryloyl chloride in dichloromethane, reacting at 25° C.; dissolving lipoic acid in toluene and adding hydroxyethyl methacrylate, reacting at 85° C.; 3) dissolving N-acryloyltaurine and lipoic acid methacryloyloxyethyl ester and reacting at 60˜65° C., dropping the polymer solution into deionized water, adding dithiothreitol and reacting at 25˜30° C. to obtain reduction sensitive nano micelles after freeze-drying. The nano micelles have regular morphology and uniform distribution, and can be used as drug carriers for controlled release.

公开(公告)号：US20210109025A1

公开(公告)日：2021-04-15

申请号：US17082894

申请日：2020-10-28

Applicant: JIANGNAN UNIVERSITY

Inventor： Gang Shi ,  Ying Li ,  Jie Chen ,  Xuan Jin ,  Likui Wang ,  Dawei Wang ,  Jingguo Yang ,  Xinxin Sang ,  Caihua Ni

IPC: G01N21/65 ,  C23C30/00

Abstract: The present invention discloses an SERS substrate of a metal-modified semiconductor-based bionic compound eye bowl structure and a construction method, and belongs to the technical field of nano materials. The present invention is based on a multi-time interface self-assembly method. Firstly, a small ball template is constructed by using a gas-liquid interface assembly process. Then, a semiconductor bowl structure array is induced to be formed by the template by using a solid-liquid interface assembly process. Next, a semiconductor bowl is assembled to a surface of a pyramid-shaped cone to form a bionic compound eye structure by using a transfer process. Finally, a surface of the bionic compound eye structure is modified with a layer of uniformly distributed metal particles by a physical deposition method or a chemical deposition method, thereby forming the SERS substrate of the metal-modified semiconductor-based bionic compound eye bowl structure.

公开(公告)号：US10933028B2

公开(公告)日：2021-03-02

申请号：US16494993

申请日：2018-12-03

Applicant: JIANGNAN UNIVERSITY

Inventor： Liping Zhang ,  Caihua Ni ,  Ren Liu ,  Dawei Wang ,  Gang Shi ,  Xinxin Sang ,  Xiaofeng Xia

IPC: A61K9/51 ,  A61K31/337 ,  A61K31/351

Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

公开(公告)号：US11623968B2

公开(公告)日：2023-04-11

申请号：US16954734

申请日：2019-11-26

Applicant: JIANGNAN UNIVERSITY

Inventor： Liping Zhang ,  Caihua Ni ,  Ren Liu ,  Gang Wang

IPC: C08B37/00 ,  A61K9/107 ,  A61K9/14 ,  A61K31/723 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: A method for making xanthan gum copolymer nanomicelles comprising: 1) degrading xanthan gum in aqueous solution to obtain degraded xanthan gum; 2) preparing xanthan gum bromide from the degraded xanthan gum; 3) preparing xanthan gum copolymer from the xanthan gum bromide and 4) making the gum copolymer nanomicelles from the xanthan gum copolymer. The xanthan gum copolymer nanomicelles have good morphological regularity, good biocompatibility and stable performance as an anticancer drug carriers.

公开(公告)号：US11214716B2

公开(公告)日：2022-01-04

申请号：US17195380

申请日：2021-03-08

Applicant: JIANGNAN UNIVERSITY

Inventor： Gang Shi ,  Ying Li ,  Hongyan Miao ,  Caihua Ni

IPC: C09J161/14 ,  C09J161/06 ,  C08G8/24 ,  C08G8/28

Abstract: The present invention relates to a phenol-based resin adhesive from lignin pyrolysis, comprising a polymer of phenol and formaldehyde from lignin pyrolysis, wherein the phenol from lignin pyrolysis comprises at least two phenols from lignin pyrolysis or at least two lignin-modified phenols from lignin pyrolysis. A repeat unit of the polymer of phenol and formaldehyde from lignin pyrolysis comprises at least two phenol units from lignin pyrolysis or at least two lignin-modified phenol units from lignin pyrolysis. According to the phenol-based resin adhesive from lignin pyrolysis in the present invention, by-products during the pyrolysis of lignin for power generation are used as raw materials, so it is environment-friendly and economical.

公开(公告)号：US20210114868A1

公开(公告)日：2021-04-22

申请号：US17082878

申请日：2020-10-28

Applicant: JIANGNAN UNIVERSITY

Inventor： Gang Shi ,  Ying Li ,  Jianhua Li ,  Xuan Jin ,  Dawei Wang ,  Likui Wang ,  Jingguo Yang ,  Xinxin Sang ,  Caihua Ni

IPC: B81B7/04 ,  B81C1/00 ,  B81C99/00 ,  C23C18/16 ,  C23C18/38 ,  C23C18/42 ,  B82Y30/00 ,  B82Y40/00 ,  G01N33/02 ,  G01N21/65

Abstract: The present invention discloses a bionic SERS substrate of a metal-based compound eye bowl structure, a construction method and application. The bionic SERS substrate of the metal-based compound eye bowl structure of the present invention consists of a metal bowl and a cone-shaped structure substrate in an ordered hierarchy manner. The metal bowl is of a continuously and closely arranged single-layer bowl structure. A height of the metal bowl is 0.01-10 μm, and a bowl opening diameter is 0.01-10 μm. A cone is a micron pyramid cone, and a height of the micron pyramid cone is 1-100 μm. The present invention assembles the metal bowl on a surface of the substrate of the micron pyramid cone structure with great fluctuation by a solid-liquid interface chemical reduction method and a small ball template method, and further constructs a 3D SERS substrate with a bionic compound eye structure.

公开(公告)号：US10888855B2

公开(公告)日：2021-01-12

申请号：US15748760

申请日：2016-05-12

Applicant: JIANGNAN UNIVERSITY

Inventor： Gang Shi ,  Ying Li ,  Caihua Ni ,  Dawei Wang ,  Fei He ,  Lifeng Chi ,  Nan Lv

IPC: B01J35/00 ,  H01L51/42 ,  H01L21/306 ,  B01J21/06 ,  B01J31/38 ,  B01J37/02 ,  H01L51/00 ,  C02F1/72 ,  C30B29/06 ,  C30B29/16 ,  C30B29/58 ,  C30B29/66 ,  C30B7/10 ,  C01G23/053 ,  C30B29/60 ,  C30B29/32 ,  B01J31/06 ,  C02F1/32 ,  B82Y40/00 ,  B82Y30/00 ,  C02F101/30

Abstract: The invention relates to a three-dimensional bionic composite material based on refection elimination and double-layer P/N heterojunctions. The preparation method of the composite material comprises: (1) anisotropically etching a silicon wafer with an alkaline solution, to form compactly arranged tetragonal pyramids on the surface of the silicon wafer; (2) performing hydrophilic treatment on the silicon wafer, growing TiO2 crystal seeds on the surface of the silicon wafer, and calcining the silicon wafer in a muffle furnace; (3) putting the silicon wafer obtained in the step (2) into a reaction kettle, and growing TiO2 nano-rods on the side walls of silicon cones by a hydrothermal synthesis method; and (4) depositing PPY nano-particles on the TiO2 nano-rods. The composite material has good refection elimination performance and efficient photogenerated charge separation capability, and is applicable in fields of photo-catalysis, photoelectric conversion devices, solar cells and the like.

公开(公告)号：US20240108581A1

公开(公告)日：2024-04-04

申请号：US18049244

申请日：2022-10-24

Applicant: JIANGNAN UNIVERSITY

Inventor： Liping ZHANG ,  Yi Zhu ,  Wenlong Wang ,  Caihua Ni

IPC: A61K9/16

CPC classification number: A61K9/1682 ,  A61K9/1635

Abstract: The invention provides a making method of modified polyvinyl alcohol embolic microspheres. First, polyvinyl alcohol dimethyl sulfoxide solution is added to acryloyl chloride dichloromethane solution for reaction, then taurine solution is added to the above solution for further reaction, so that functional groups are introduced into the side chains of polyvinyl alcohol, then blank microspheres are prepared by suspension crosslinking method, and finally, drug-loaded modified polyvinyl alcohol embolic microspheres are prepared. The invention aims at improving the drug loading rate and drug loading speed of the microspheres. Through modification, the crystallinity of polyvinyl alcohol is weakened, the swelling in water is accelerated, and the application effect of the microspheres is improved.