Invention Grant
- Patent Title: Method of predicting effect of treatment by PD-1/PD-L1 blockade using abnormality of PD-L1 (CD274) as index
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Application No.: US15569898Application Date: 2016-04-28
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Publication No.: US10585100B2Publication Date: 2020-03-10
- Inventor: Seishi Ogawa , Keisuke Kataoka , Kengo Takeuchi
- Applicant: KYOTO UNIVERSITY , JAPANESE FOUNDATION FOR CANCER RESEARCH
- Applicant Address: JP Kyoto JP Tokyo
- Assignee: Kyoto University,Japanese Foundation for Cancer Research
- Current Assignee: Kyoto University,Japanese Foundation for Cancer Research
- Current Assignee Address: JP Kyoto JP Tokyo
- Agency: Foley & Lardner LLP
- Priority: JP2015-093599 20150430
- International Application: PCT/JP2016/063326 WO 20160428
- International Announcement: WO2016/175275 WO 20161103
- Main IPC: G01N33/574
- IPC: G01N33/574 ; A61K39/395 ; C12Q1/68 ; C12N15/09 ; A61K45/00 ; C07K16/28 ; C07K16/18
Abstract:
An object of the present invention is to provide an effective method of predicting an effect of treatment by a PD-1/PD-L1 blockade, which is a method of predicting whether or not PD-1/PD-L1 blockade is effective for treatment of a subject suffering from a malignant tumor, which comprises detecting abnormality of genome relating to effectiveness of the PD-1/PD-L1 blockade in a tumor cell taken from the subject and evaluating the PD-1/PD-L1 blockade as useful for the treatment of the subject when there is the abnormality.
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