The present invention provides a mouse with a low friction roller module, including a mouse body and a low friction roller module; the low friction roller module is mounted in the mouse body and includes a support, a roller, a low friction bearing, a support shaft, and an encoding component; a mounting portion is provided in the roller; the low friction bearing is fastened in the mounting portion; one side of the support shaft passes through and is connected to the low friction bearing, and the other side of the support shaft passes through and is connected to the support; and the encoding component is connected to the roller. In this way, rolling friction force is reduced.