Technologies for communication with direct data placement include a number of computing nodes in communication over a network. Each computing node includes a many-core processor having an integrated host fabric interface (HFI) that maintains an association table (AT). In response to receiving a message from a remote device, the HFI determines whether the AT includes an entry associating one or more parameters of the message to a destination processor core. If so, the HFI causes a data transfer agent (DTA) of the destination core to receive the message data. The DTA may place the message data in a private cache of the destination core. Message parameters may include a destination process identifier or other network address and a virtual memory address range. The HFI may automatically update the AT based on communication operations generated by software executed by the processor cores. Other embodiments are described and claimed.