Disclosed is a system and method of directing a biosignal detector arrangement. The system for directing a biosignal detector arrangement may include a biosignal detector configured to detect a biosignal of an object, a measurer configured to obtain, in real-time, information including surface data of the object and position data associated with an arrangement of the biosignal detector relative to the object based on the surface data, a processor configured to set initially obtained information of the obtained information as reference information for a surface registration and compare the reference information to finally obtained information of the obtained information, and a display configured to display the reference information and the finally obtained information.