In one example in accordance with the present disclosure, a system for partial backup during runtime includes a memory module having a volatile memory and a non-volatile memory. The system also includes a backup controller. The backup controller determines that a backup should occur in the memory module. The backup controller determines a backup domain of the volatile memory. The backup controller causes a deactivation domain of the volatile memory to be deactivated, where the deactivation domain includes the backup domain. The backup controller causes the backup to initiate during normal runtime of the system. The backup includes data in the backup domain of the volatile memory being saved to the non-volatile memory.