The present disclosure provides a charge pump system and a method of operating the same. The charge pump system includes a first pump circuit, a second pump circuit and a control device. The first pump circuit is configured to operate in a first voltage domain. The second pump circuit is configured to operate in a second voltage domain different from the first voltage domain. The control device is configured to selectively enable one of the first pump circuit and the second pump circuit based on an operating environment, wherein the one of the first pump circuit and the second pump circuit provides a pump voltage.