Invention Grant
- Patent Title: Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma
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Application No.: US16132928Application Date: 2018-09-17
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Publication No.: US10704108B2Publication Date: 2020-07-07
- Inventor: Bert Vogelstein , Kenneth W. Kinzler , D. Williams Parsons , Xiaosong Zhang , Jimmy Cheng-Ho Lin , Rebecca J. Leary , Philipp Angenendt , Nickolas Papadopoulos , Victor Velculescu , Giovanni Parmigiani , Rachel Karchin , Sian Jones , Hai Yan , Darell Bigner , Chien-Tsun Kuan , Gregory J. Riggins
- Applicant: The Johns Hopkins University , Duke University
- Applicant Address: US MD Baltimore US NC Durham
- Assignee: The Johns Hopkins University,Duke University
- Current Assignee: The Johns Hopkins University,Duke University
- Current Assignee Address: US MD Baltimore US NC Durham
- Agency: Fish & Richardson P.C.
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K31/00 ; C12Q1/6886
Abstract:
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
Public/Granted literature
- US20190106752A1 GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA Public/Granted day:2019-04-11
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