A transmitter is configured to generate a DOCSIS signal for transmission onto a frequency-selective coaxial cable. The transmitter comprises a first reverse tilt filter circuit, a digital predistortion circuit, a forward tilt filter, a wideband equalizer, a second reverse tilt filter, and a power amplifier. The responses of the tilt filters may be set based on the frequency response of the frequency-selective coaxial cable to which the transmitter is intended to be coupled. The predistortion circuit may compensate for distortion introduced by circuitry of the transmitter. The equalizer circuit may be operable to compensate for undesired linear response of other circuitry of the transmitter.