Invention Grant
- Patent Title: Label-free cellular manipulation and sorting via biocompatible ferrofluids
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Application No.: US15670264Application Date: 2017-08-07
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Publication No.: US10782223B2Publication Date: 2020-09-22
- Inventor: Hur Koser
- Applicant: Yale University
- Applicant Address: US CT New Haven
- Assignee: YALE UNIVERSITY
- Current Assignee: YALE UNIVERSITY
- Current Assignee Address: US CT New Haven
- Agency: Riverside Law LLP
- Main IPC: G01N15/10
- IPC: G01N15/10 ; B03C1/32 ; B03C1/023 ; B03C1/23 ; B03C1/28 ; B03C1/253 ; B01L3/00 ; C12M1/00 ; C12N13/00 ; G01N15/00

Abstract:
A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one output, and a length between the sample inlet and the at least one output, wherein a sample can be added to the sample inlet and flow along the length to the at least one outlet. The device includes a plurality of electrodes, wherein the microfluidic channel length transverses the plurality of electrodes, and further includes a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel. The present invention also includes a method for separating at least one cell type. The method includes the steps of suspending cells in a bio-compatible ferrofluid to form a sample, passing the sample through a microfluidic channel that transverses a plurality of electrodes, applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel, and sorting the cells into at least one output channel based on a variation of at least one of cell size, shape and elasticity.
Public/Granted literature
- US20180128729A1 Label-Free Cellular Manipulation and Sorting Via Biocompatible Ferrofluids Public/Granted day:2018-05-10
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