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公开(公告)号：US20180128729A1
公开(公告)日：2018-05-10
申请号：US15670264
申请日：2017-08-07
Applicant: Yale University
Inventor： Hur Koser
IPC: G01N15/10 , B03C1/28 , B01L3/00 , B03C1/023 , B03C1/23 , B03C1/253 , B03C1/32 , C12M1/00 , C12N13/00 , G01N15/00
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one output, and a length between the sample inlet and the at least one output, wherein a sample can be added to the sample inlet and flow along the length to the at least one outlet. The device includes a plurality of electrodes, wherein the microfluidic channel length transverses the plurality of electrodes, and further includes a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel. The present invention also includes a method for separating at least one cell type. The method includes the steps of suspending cells in a bio-compatible ferrofluid to form a sample, passing the sample through a microfluidic channel that transverses a plurality of electrodes, applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel, and sorting the ceils into at least one output channel based on a variation of at least one of cell size, shape and elasticity.
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Patent Agency Ranking
公开(公告)号：US09726592B2
公开(公告)日：2017-08-08
申请号：US15163890
申请日：2016-05-25
Applicant: Yale University
Inventor： Hur Koser
IPC: G01N33/00 , G01N27/26 , G01N15/10 , B03C1/253 , B01L3/00 , B03C1/23 , C12M1/00 , C12N13/00 , B03C1/023 , B03C1/28 , B03C1/32 , B01D35/06 , G01N15/00
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/06 , B01L2300/0848 , B03C1/023 , B03C1/23 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , C12M47/04 , C12N13/00 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described, The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.
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3.发明申请Label-Free Cellular Manipulation and Sorting Via Biocompatible Ferrofluids 审中-公开通过生物相容性铁磁流体进行无标记细胞操作和分选公开(公告)号：US20150151299A1
公开(公告)日：2015-06-04
申请号：US14591492
申请日：2015-01-07
Applicant: Yale University
Inventor： Hur Koser
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/06 , B01L2300/0848 , B03C1/023 , B03C1/23 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , C12M47/04 , C12N13/00 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described, The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.
Abstract translation: 描述了用于分离悬浮在生物相容性铁磁流体中的细胞样品的装置，该装置包括具有样品入口，至少一个出口和相同入口与至少一个出口之间的长度的微流体通道，其中样品 可以添加到样品入口并沿着微流体通道长度流动到至少一个出口。 该装置包括多个电极和用于向多个电极施加电流以产生沿着微流体通道长度的磁场图案的电源。 本发明还包括使用所述装置来分离至少一种细胞类型的方法。
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公开(公告)号：US10782223B2
公开(公告)日：2020-09-22
申请号：US15670264
申请日：2017-08-07
Applicant: Yale University
Inventor： Hur Koser
IPC: G01N15/10 , B03C1/32 , B03C1/023 , B03C1/23 , B03C1/28 , B03C1/253 , B01L3/00 , C12M1/00 , C12N13/00 , G01N15/00
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one output, and a length between the sample inlet and the at least one output, wherein a sample can be added to the sample inlet and flow along the length to the at least one outlet. The device includes a plurality of electrodes, wherein the microfluidic channel length transverses the plurality of electrodes, and further includes a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel. The present invention also includes a method for separating at least one cell type. The method includes the steps of suspending cells in a bio-compatible ferrofluid to form a sample, passing the sample through a microfluidic channel that transverses a plurality of electrodes, applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel, and sorting the cells into at least one output channel based on a variation of at least one of cell size, shape and elasticity.
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公开(公告)号：US20160266026A1
公开(公告)日：2016-09-15
申请号：US15163890
申请日：2016-05-25
Applicant: Yale University
Inventor： Hur Koser
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/06 , B01L2300/0848 , B03C1/023 , B03C1/23 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , C12M47/04 , C12N13/00 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described, The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.
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6.发明授权Label-free cellular manipulation and sorting via biocompatible ferrofluids 有权通过生物相容的铁磁流体进行无标记的细胞操纵和分选公开(公告)号：US09352317B2
公开(公告)日：2016-05-31
申请号：US14591492
申请日：2015-01-07
Applicant: Yale University
Inventor： Hur Koser
CPC classification number: G01N15/1056 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/06 , B01L2300/0848 , B03C1/023 , B03C1/23 , B03C1/253 , B03C1/288 , B03C1/32 , B03C2201/18 , B03C2201/24 , B03C2201/26 , C12M47/04 , C12N13/00 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
Abstract: A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described, The device includes a microfluidic channel having a sample inlet, at least one outlet and a length between the same inlet and the at least one outlet, wherein a sample can be added to the sample inlet and flow along the microfluidic channel length to the at least one outlet. The device includes a plurality of electrodes and a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the microfluidic channel length. The present invention also includes a method of using said device for separating at least one cell type.
Abstract translation: 描述了用于分离悬浮在生物相容性铁磁流体中的细胞样品的装置，该装置包括具有样品入口，至少一个出口和相同入口与至少一个出口之间的长度的微流体通道，其中样品 可以添加到样品入口并沿着微流体通道长度流动到至少一个出口。 该装置包括多个电极和用于向多个电极施加电流以产生沿着微流体通道长度的磁场图案的电源。 本发明还包括使用所述装置来分离至少一种细胞类型的方法。
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