Methods, systems, and computer readable media for lock-free communications processing at a network node are disclosed. One method occurs at a first network node configured to add messages to a plurality of queues, wherein each of the plurality of queues is accessed by one of a plurality of threads. The method comprises receiving a first message associated with a first mobile subscriber; determining that the first message is associated with a first partition key; assigning, based on the first partition key, the first message to a first queue of the plurality of queues, wherein the first queue includes messages associated with the first mobile subscriber and wherein the first queue is accessible by a first thread of the plurality of threads; and processing, by the first thread, messages of the first queue in a first in, first out order.