Invention Grant
- Patent Title: Stimulated Raman spectroscopic microscope by resonant delay-line tuning
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Application No.: US16470119Application Date: 2017-12-14
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Publication No.: US10928324B2Publication Date: 2021-02-23
- Inventor: Chien-Sheng Liao , Pu Wang , Ji-Xin Cheng
- Applicant: Purdue Research Foundation , Chien-Sheng Liao , Pu Wang , Ji-Xin Cheng
- Applicant Address: US IN West Lafayette; US MA Brighton; US IN West Lafayette; US MA Newton
- Assignee: Purdue Research Foundation,Chien-Sheng Liao,Pu Wang,Ji-Xin Cheng
- Current Assignee: Purdue Research Foundation,Chien-Sheng Liao,Pu Wang,Ji-Xin Cheng
- Current Assignee Address: US IN West Lafayette; US MA Brighton; US IN West Lafayette; US MA Newton
- Agency: Gutwein Law
- Agent Tyler B. Droste
- International Application: PCT/US2017/066424 WO 20171214
- International Announcement: WO2018/118646 WO 20180628
- Main IPC: G01J3/44
- IPC: G01J3/44 ; G01N21/65 ; G01J3/10 ; G01J3/433

Abstract:
A microsecond-scale stimulated Raman spectroscopic imaging system having a light source, such as a laser output that provides two femtosecond laser beams and a modulator to modulate the laser intensity at frequency between about 1 and about 100 megahertz. The system can further include a medium that chirps the two femtosecond beams to generate a spectral focus in a specimen, and a galvo mirror or resonant mirror pair to scan the two femtosecond beams in two dimension on the specimen. An objective lens can focus the two laser beams into a specimen or sample and a resonant delay scanner configured to produce an optical delay to the pair of chirped beams in said specimen and a tuned amplifier or lock-in amplifier can be used to extract the stimulated Raman-signal shift at the aforementioned modulation frequency.
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