A mechanism is described for facilitating general purpose input/output data capture and neutral cache system for autonomous machines. A method of embodiments, as described herein, includes capturing, by an image capturing device, one or more images of one or more objects, where the one or more images represent input data associated with a neural network. The method may further include determining accuracy of first output results generated by a default neural caching system by comparing the first output results with second output results predicted by a custom neural caching system. The method may further include outputting, based on the accuracy, a final output results including at least one of the first output results or the second output results.