Invention Grant
- Patent Title: Method and apparatus for the analysis of molecules using mass spectrometry and optical spectroscopy
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Application No.: US16743197Application Date: 2020-01-15
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Publication No.: US11043366B2Publication Date: 2021-06-22
- Inventor: Alexander Makarov , Oleg Boyarkine , Vladimir Kopysov
- Applicant: Thermo Fisher Scientific (Bremen) GmbH , ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
- Applicant Address: DE Bremen; CH Lausanne
- Assignee: Thermo Fisher Scientific (Bremen) GmbH,ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
- Current Assignee: Thermo Fisher Scientific (Bremen) GmbH,ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
- Current Assignee Address: DE Bremen; CH Lausanne
- Agent David A. Schell
- Priority: GB1418436 20141017
- Main IPC: H01J49/00
- IPC: H01J49/00

Abstract:
A method of analyzing molecules, comprising: generating ions from a sample of molecules; cooling the generated ions below ambient temperature; fragmenting at least some of the cooled ions by irradiating the ions with light at a plurality of different wavelengths (λ) within one or more predetermined spectral intervals; recording a fragment mass spectrum of the fragmented ions comprising a detected signal (I) versus m/z over a predetermined range of m/z values for each of the plurality of different wavelengths (λ), thereby recording a two-dimensional dependency of the detected signal (I) on m/z and irradiation wavelength (λ); and determining from the recorded two-dimensional dependency an identity of at least one of the generated ions and/or relative abundances of different generated ions and thereby determining an identity of at least of one of the molecules and/or relative abundances of different molecules in the sample.
Public/Granted literature
- US20200152435A1 Method and Apparatus for the Analysis of Molecules Using Mass Spectrometry and Optical Spectroscopy Public/Granted day:2020-05-14
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