The disclosure provides a preparation method of a hollow porous spherical particle artificial bone. The method comprises: (1) uniformly mixing bioceramic powder, bioglass powder and an excipient to obtain a solid-phase mixture, then adding binder solution to the solid-phase mixture, and uniformly mixing to obtain a plastic wet material; (2) loading a plastic wet material into an extrusion device of an extrusion rounder to be extruded by the orifice plate of the extrusion device to form a strip-shaped material; (3) putting the strip-shaped material into the spheronization device, cutting, and then spheronizing to form spherical particles; and (4) placing the spherical particles into a furnace, debinding, removing the excipient and the binder, and then sintering at 750-1550° C.