A method for cross-domain service optimization is implemented on a computing device and includes defining at least one key quality indicator (KQI) target for at least one end-to-end (E2E) service, where the at least one E2E service crosses more than one domain of a communications network, receiving an indication of quality of experience (QoE) for the at least one E2E service, based on the indication of QoE, translating the at least one KQI target to at least one set of service optimization instructions for each domain from among the more than one domain, and for each domain, applying the service optimization instructions.